Synthesis and Evaluation of 4-(2-Chloroquinolin-3-Yl)-6-(6-Methyl-1H-Benzimidazol-2-Yl)Pyrimidin-2-Amines as Potent Anthelmintic Agents
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چکیده
منابع مشابه
2-Methyl-6-(6-methyl-1H-benzimidazol-2-yl)phenol–2-methyl-6-(5-methyl-1H-benzimidazol-2-yl)phenol (3/1)
The title compound, 0.75C(15)H(14)N(2)O·0.25C(15)H(14)N(2)O, is a co-crystal of 2-methyl-6-(6-methyl-1H-benzimidazol-2-yl)phenol as the major component and 2-methyl-6-(5-methyl-1H-benz-imidazol-2-yl)phenol as the minor component. The refined site-occupancy ratio is 0.746 (4)/0.254 (4). The conformations of both components are identical except for that of the methyl substituent on the benzene ri...
متن کامل2-Methoxy-6-(6-methyl-1H-benzimidazol-2-yl)phenol
The mol-ecule of the title compound, C(15)H(14)N(2)O(2) is almost planar, the dihedral angle between the 6-methyl-1H-benz-imidazole plane and the 2-methoxy-phenol plane being 6.9 (2)°. An intra-molecular O-H⋯N hydrogen bond is present. Adjacent mol-ecules are linked by N-H⋯O hydrogen bonds into a three-dimensional network structure. The benzoimidazole methyl group and its attached C atom are po...
متن کاملDesign and Synthesis of 2-Methyl and 2-Methyl-4-Nitro Imidazole Derivatives as Antifungal Agents
Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...
متن کامل2-Methoxy-6-(6-methyl-1H-benzimidazol-2-yl)phenol
In the title mol-ecule, C(15)H(14)N(2)O(2), the substituted benzene ring forms a dihedral angle of 4.15 (1)° with the benzimidazole ring system. An intra-molecular O-H⋯N hydrogen bond generates an S(6) ring motif. In the solid state, mol-ecules are linked into chains along the [001] via inter-molecular bifurcated N-H⋯(O,O) hydrogen bonds, which generate R(1) (2)(5) ring motifs. The crystal pack...
متن کامل2-(1H-Benzimidazol-2-yl)-4-nitrophenol
The title compound, C(13)H(9)N(3)O(3), was prepared by the reaction of 5-nitro-salicyl-aldehyde with 1,2-diamino-benzene in methanol. The whole mol-ecule is approximately planar, with a mean deviation from the plane defined by the non-H atoms of 0.0311 (4) Å, and with a dihedral angle between the benzene ring and the benzimidazole ring system of 1.1 (3)°. An intra-molecular O-H⋯N hydrogen bond ...
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ژورنال
عنوان ژورنال: American Journal of PharmTech Research
سال: 2018
ISSN: 2249-3387
DOI: 10.46624/ajptr.2018.v8.i6.015